Table 1 CYP450s mentioned in this article and brief descriptions of their functions
From: Hydroxylases involved in terpenoid biosynthesis: a review
Classification | CYP450s | Functions |
|---|---|---|
Monoterpene hydroxylases | CYP76C1 | Linalool hydroxylase |
| Â | CYP76C2 | Citronellol 8-hydroxylase |
| Â | CYP76C4 | Linalool hydroxylase |
| Â | CYP76B6 | Nerol 8-hydroxylase |
| Â | CYP71B31 | Linalool hydroxylase |
| Â | CYP76C3 | Linalool hydroxylase |
| Â | CYP76F45 | Geraniol 8-hydroxylase |
| Â | CYP6BH5 | Geraniol 8-hydroxylase |
| Â | CYP153A6 | Limonene 7-hydroxylase |
| Â | CYP750B1 | (+)-Sabinene synthase |
| Â | CYP76AA25 | Sabinene-hydroxylase |
| Â | CYP345E2 | Limonene-hydroxylase |
| Â | CYP6DE1 | Pinene-hydroxylase |
| Â | CYP6DE3 | Pinene-hydroxylase |
| Â | CYP6DJ1 | Limonene-hydroxylase |
| Â | CYP71D12 | Tabersonine hydroxylase |
| Â | CYP71D351 | Tabersonine hydroxylase |
| Â | CYP71BJ1 | Tabersonine hydroxylase |
Sesquiterpene hydroxylases | CYP71AV2 | GA oxidase |
| Â | CYP71BL2 | GAA 6-hydroxylase |
| Â | CYP71BL1 | GAA 8-hydroxylase |
| Â | CYP71AV9 | GA hydroxylase |
| Â | CYP71BL5 | Costunolide synthase |
| Â | CYP260A1 | Unspecific monooxygenase |
| Â | CYP264B1 | Unspecific monooxygenase |
| Â | CYP71AV1 | Amorpha-4,11-diene monooxygenase |
| Â | CYP71AV8 | (+)-Valencene hydroxylase |
| Â | CYP109B1 | Valencene oxidase |
|  | CYP71BE5 | α-Guaiene hydroxylase |
| Â | CYP71D51V2 | (+)-Valencene 2-hydroxylase |
| Â | CYP183A1 | Pentalenene 13-hydroxylase |
| Â | CYP170A1 | epi-Isozizaene monooxygenase |
Diterpene hydroxylases | CYP71D16 | CBT-ol 6-hydroxylase |
|  | CYP102A1 F87A/I263L | β-CBT-diol 9-hydroxylase |
|  | CYP102A1 L75A/V78A/F87G | β-CBT-triol 10-hydroxylase |
| Â | CYP726A14 | Casbene 5-oxidase |
| Â | CYP726A17 | Casbene 5-oxidase |
| Â | CYP726A18 | Casbene 5-oxidase |
| Â | CYP726A16 | 5-Keto-casbene 7,8-epoxylase |
| Â | CYP726A15 | Neocembrene 5-oxidase |
| Â | CYP726A19 | Casbene 5-oxidase |
| Â | CYP71D445 | Casbene hydroxylase |
| Â | CYP726A27 | Casbene hydroxylase |
| Â | CYP76AH1 | Ferruginol synthase, ferruginol 11-hydroxylase |
| Â | CYP76AH4 | Ferruginol synthase, ferruginol 11-hydroxylase |
| Â | CYP76AH5 | Ferruginol synthase, ferruginol 11-hydroxylase |
| Â | CYP76AH6 | Ferruginol synthase, ferruginol 11-hydroxylase |
| Â | CYP76AH7 | Ferruginol synthase, ferruginol 11-hydroxylase |
| Â | CYP76AH22 | Ferruginol synthase, ferruginol 11-hydroxylase |
| Â | CYP76AH23 | Ferruginol synthase, ferruginol 11-hydroxylase |
| Â | CYP76AH24 | Ferruginol synthase, ferruginol 11-hydroxylase |
| Â | CYP76AK6 | 11-Hydroxyferruginol 20-oxidase, miltiradiene 20-hydroxylase |
| Â | CYP76AK7 | 11-Hydroxyferruginol 20-oxidase, miltiradiene 20-hydroxylase |
| Â | CYP76AK8 | 11-Hydroxyferruginol 20-oxidase, miltiradiene 20-hydroxylase |
| Â | CYP76AH3 | Ferruginol oxidase |
| Â | CYP76AK1 | 11-Hydroxyferruginol 20-oxidase |
| Â | CYP720B1 | Resin acids 18-oxidase |
| Â | CYP720B4 | Resin acids 18-oxidase |
| Â | CYP725A1 | Taxane 10-hydroxylase |
| Â | CYP725A2 | Taxane 13-hydroxylase |
| Â | CYP725A3 | Taxane 14-hydroxylase |
| Â | CYP725A4 | Taxadiene 5-monoxygenase |
| Â | CYP725A5 | taxane 2-hydroxylase |
| Â | CYP725A6 | Taxane 7-hydroxylase |
| Â | CYP701A3 | ent-Kaurene 18-oxidase |
| Â | CYP88A3 | ent-Kaurenoic acid 7-oxidase |
| Â | CYP88A4 | ent-Kaurenoic acid 7-oxidase |
| Â | CYP714A1 | GA12 16-carboxidase |
| Â | CYP714A2 | Gas hydroxylase |
Triterpene hydroxylases | CYP716A47 | Dammarenediol-II 12-hydroxylase |
| Â | CYP716A53v2 | Protopanaxadiol 6-hydroxylase |
| Â | CYP87D18 | Cucurbitadienol 11-hydroxylase |
| Â | CYP81Q58 | 19-Hydroxycucurbitadienol-25-oxidase |
| Â | CYP88L2 | Cucurbitadienol-19-hydroxylase |
|  | CYP88D6 | β-Amyrin 11-oxidase |
|  | CYP72A154 | 11-Oxo-β-amyrin 30-oxidase |
|  | CYP72A63 | β-Amyrin 30-hydroxylase |
|  | CYP72A61v2 | 24-Hydroxy-β-amyrin 22-hydroxylase |
| Â | CYP72A68v2 | Oleanolic acid 24-oxidase |
|  | CYP93E2 | β-Amyrin 24-hydroxylase |
|  | CYP93E3 | β-Amyrin 24-hydroxylase |
|  | CYP716A12 | β-Amyrin 28-hydroxylase |
|  | CYP93E1 | β-Amyrin 24-hydroxylase |
|  | CYP716A94 | β-Amyrin 28-hydroxylase |
|  | CYP716AL1 | β-Amyrin 28-hydroxylase |
|  | CYP716A175 | β-Amyrin 28-hydroxylase |
|  | CYP716A52v2 | β-Amyrin 28-hydroxylase |
|  | CYP716A179 | β-Amyrin 28-hydroxylase |
|  | CYP716A1 | β-Amyrin 28-hydroxylase |
|  | CYP716A2 | β-Amyrin 28-hydroxylase |
|  | CYP716A44 | β-Amyrin oxidase, α-amyrin oxidase |
|  | CYP716A46 | β-Amyrin oxidase, α-amyrin oxidase |
|  | CYP716E26 | β-Amyrin 6-hydroxylase |
|  | CYP716A75 | β-Amyrin 28-oxidase, 16α-hydroxy-β-amyrin 28-oxidase |
|  | CYP716A253 | β-Amyrin 28-oxidase |
|  | CYP716A252 | α-Amyrin 28-oxidase |
|  | CYP716Y1 | β-Amyrin 16-hydroxylase, α-amyrin 16-hydroxylase |
| Â | CYP72A397 | Oleanolic acid 23-hydroxylase |
| Â | CYP72A67 | Oleanolic acid 2-hydroxylase, hederagenin 2-hydroxylase |
| Â | CYP72A68 | Oleanolic acid oxidase |
|  | CYP51H10 | β-Amyrin oxidase |
Tetraterpene hydroxylases | CYP175A1 | β-Carotene β-ring hydroxylase |
|  | CYP97A3 | β-Carotene β-ring hydroxylase |
|  | CYP97C1 | β-Carotene β-ring hydroxylase, β-carotene ε-ring hydroxylase |
|  | CYP97A4 | β-Carotene β-ring hydroxylase |
|  | CYP97C2 | Zeinoxanthin ε-ring hydroxylase |
|  | CYP97B29 | β-Carotene β-ring hydroxylase |
| Â | CYP97B3 | Carotenoid oxidase |