Development of a Pichia pastoris cell factory for efficient production of germacrene A: a precursor of β-elemene

Bioresources and Bioprocessing

Table 1 Production of germacrene A in metabolically engineered strains

Host	Shake flask fermentation (mg/L)	Fed-batch fermentation	References
E. coli	126	–	Chen et al. (2023)
E. coli	364	–	Li et al. (2022)
S. cerevisiae	190	–	Hu et al. (2017)
S. cerevisiae	310	–	Zhang et al. (2021)
O. polymorpha	509	4.7 g/L	Ye et al. (2023)
P. pastoris	335	1.9 g/L	This study