Table 1 The advances of lycopene production by Y. lipolytica

Glucose

Adjusted of the copy number of three heterologous lycopene biosynthesis genes (crtE, crtB and crtI) and overexpressed of AMP deaminase coding gene (AMPD)

Fed-batch

46–60 mg/g

Zhang et al. (2019)

Mixed substrate (glucose and fatty acid et al.)

Synthesized of carotenoid precursors IPP and DMAPP through the IUP

Fed-batch

4.2 g/L

Luo et al. (2020)

Glucose

Released the substrate inhibition of lycopene cyclase

Fed-batch

17.6 g/L

Ma et al. (2022)

Glucose

Overexpressed of endogenous HMGS from Y. lipolytica and HMGR from Bordetella petrii

Fed-batch

1.96 g/L

Cui et al. (2019)

Glucose

Deleted of POX1-POX6 and GUT2, expressed of PacrtB, PacrtI, crtE and hmgr

Fed-batch

16 mg/g DCW

Gatter et al. (2016)

Glycerol

Employed different methods to improve the key genes overexpression including crtE, crtB, crtI, AtoB, HMGR, ERG12

Fed-batch

5.1 g/L

This study