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Bioresources and Bioprocessing
Fig. 1 | Bioresources and Bioprocessing

Fig. 1

From: Harnessing ceramic hydroxyapatite as an effective polishing strategy to remove product- and process-related impurities in bispecific antibody purification

Fig. 1

A Ceramic hydroxyapatite (CHT) binding (left) and elution (right) mechanisms. There are two types of binding sites on CHT medium, a calcium-site (C-site) (top) and a phosphate-site (P-site) (bottom). B The addition of suitable salts (high concentration of NaCl (top); low concentration of phosphate (bottom)) enables stronger binding between biomolecules and the CHT binding sites

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