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Bioresources and Bioprocessing
Fig. 2 | Bioresources and Bioprocessing

Fig. 2

From: Harnessing ceramic hydroxyapatite as an effective polishing strategy to remove product- and process-related impurities in bispecific antibody purification

Fig. 2

Three bispecific antibodies (bsAbs), used as model molecules in this study, including two asymmetric molecules with heterodimeric knob-in-to-hole Fc and one symmetric molecule with homodimeric wild-type Fc. Molecule A, “1 + 1” valency; Molecule B, “2 + 1” valency; Molecule C, “2 + 2” valency. Abbreviations: LC = Light chain; HCK = Heavy chain knob; scFv-FcH = scFv-Fc hole; VH-CH1-scFv-FcH = VH-CH1-scFv-Fc hole; and VH-CH1-scFv-FcW = VH-CH1-scFv-Fc wild type

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