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Bioresources and Bioprocessing
Fig. 9 | Bioresources and Bioprocessing

Fig. 9

From: Harnessing ceramic hydroxyapatite as an effective polishing strategy to remove product- and process-related impurities in bispecific antibody purification

Fig. 9

Mechanistic illustrations during CHT-P (top) and CHT-NaCl (bottom) gradient elution. Differences in interactions between large LMWs vs monomers to C- and P-sites on CHT resulted in better separation resolution by CHT-P over CHT-NaCl. Numbers of dotted lines, NaCl and phosphate molecules are used for an illustration purpose to compare protein-CHT binding behaviour (from left to right) during CHT-NaCl and CHT-P gradient elution, but not quantitatively

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