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Bioresources and Bioprocessing
Fig. 4 | Bioresources and Bioprocessing

Fig. 4

From: Collagen type II solution extracted from supercritical carbon dioxide decellularized porcine cartilage: regenerative efficacy on post-traumatic osteoarthritis model

Fig. 4

Effects of the Col II solution on cartilage and bone damage in MNX-induced osteoarthritis in rats by histological analysis and scoring for cartilage repair in rat knee joints. The pathological changes in rat knee joints were examined by H&E stain (a), scoring (b) 6 weeks after MNX treatment (magnification: × 40). The red colour arrow indicates cartilage damage. The blue colour arrow indicates mild cartilage damage. The green and black colour arrow indicates cartilage damage preservation. Data are means ± standard deviation (SD) (n = 6). *p < 0.05 compared with N Group; #p < 0.05 compared with OA group; ##p < 0.001 compared with OA group

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