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Table 4 The terpenoid production increased in this study and previous studies

From: Enhanced limonene production by optimizing the expression of limonene biosynthesis and MEP pathway genes in E. coli

Products Production increased Genes overexpressed References
Isoprene 0.4-fold dxs and dxra Xue et al. [16]
Phytoene 2.1-fold idi Kajiwara et al. [36]
Isoprene 2.3-fold dxs and dxr Zhao et al. [17]
β-Carotene 2.7-fold idi Kajiwara et al. [36]
Abietadiene 2.8-fold dxs, dxr and idi Morrone et al. [33]
Squalene 2.9-fold dxs and idi Ghimire et al. [37]
Limonene 3.4-fold dxs and idi This work
Carotenoids 3.5-fold dxs, dxr and idi Albrecht et al. [38]
Isoprene 4.0-fold dxs, ispGb, ispHc, idi, ispEd, dxr, ispDe and ispFf Zurbriggen et al. [18]
Lycopene 4.5-fold idi Kajiwara et al. [36]
Isoprene 4.8-fold dxs, dxr and idi Lv et al. [19]
Taxadiene 15.6-fold dxs, idi ispD and ispF Ajikumar et al. [14]
Levopimaradiene 611.3-fold dxs, idi ispD and ispF Leonard et al. [15]
  1. The rate-limiting enzymes in the MEP pathway were overexpressed in all the studies listed in this table.
  2. aThe gene of 1-deoxy-d-xylulose-5-phosphate reductoisomerase;
  3. bThe gene of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate synthase;
  4. cThe gene of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase;
  5. dThe gene of 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase;
  6. eThe gene of 2-c-methyl-d-erythrtol-4-phosphate cytidyltransferase;
  7. fThe gene of 2-c-methyl-d-erythritol 2, 4-cyclodiphosphate synthase.