Bioreductive preparation of ACE inhibitors precursor (R)-2-hydroxy-4-phenylbutanoate esters: Recent advances and future perspectives

Bioresources and Bioprocessing

Table 1 Asymmetric reduction of OPBE into ( R )-HPBE employing microorganisms

Entry	Strains	OPBE loading [g L ⁻¹ ]	ee [%]	Yield[%]	Reference
1	Candida krusei SW2026	2.5	99.7	95.1	[17]
2	Bacillus pumilus Phe-C3	6.2	97.1	91	[37]
3	Candida boidinii CIOC21	2	99	92	[36]
4	Baker’s yeast	1	92	90	[38]
5	Candida holmi	4.1	90	58	[33]
6	Pichia angusta	1.4	81	99	[34]
7	Pichia pastoris	1	95	99	[7]