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Table 2 A comparison of rapamycin production by using SSF inoculation with other conventional liquid seed fermentations

From: Using the mycelium-covered cereals as an efficient inoculation method for rapamycin fermentation in a 15-L fermenter using Streptomyces hygroscopicus

Carbon source Bioreactor Mode Max. rapamycin (mg/L) Rapamycin productivity (mg/L h) References
Glucose 5 L Batch 780 4.33 (Yen and Hsiao 2013)
Fructose 5 L Batch 723 6.0 (Yen and Li 2014)
Glycerol, fructose 130 L Fed-batch 110 1.0 (Chen et al. 1999)
Glycerol, fructose 5 L Fed-batch 500 4.17 (Chen et al. 2008)
Dextrin, glycerol 120 L Fed-batch 812 5.08 (Zhu et al. 2010)
Glucose 15 L Batch + SSF 520 3.61 This study