Table 2 A comparison of rapamycin production by using SSF inoculation with other conventional liquid seed fermentations
Carbon source | Bioreactor | Mode | Max. rapamycin (mg/L) | Rapamycin productivity (mg/L h) | References |
|---|---|---|---|---|---|
Glucose | 5 L | Batch | 780 | 4.33 | (Yen and Hsiao 2013) |
Fructose | 5 L | Batch | 723 | 6.0 | (Yen and Li 2014) |
Glycerol, fructose | 130 L | Fed-batch | 110 | 1.0 | (Chen et al. 1999) |
Glycerol, fructose | 5 L | Fed-batch | 500 | 4.17 | (Chen et al. 2008) |
Dextrin, glycerol | 120 L | Fed-batch | 812 | 5.08 | (Zhu et al. 2010) |
Glucose | 15 L | Batch + SSF | 520 | 3.61 | This study |