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Bioresources and Bioprocessing
Fig. 5 | Bioresources and Bioprocessing

Fig. 5

From: Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism

Fig. 5

Metabolic flux distribution. a The calculated values of flux were normalized with respect to that of the low proportion between asparagine and glutamine. The line size was increased with the value of flux. The figure indicated that TCA cycle was strengthened in high proportion condition. b Metabolism of high proportion between glutamine and asparagine in CHO-DHFR cell lines. Glutamate and aspartate tended to flow into TCA cycle for immediate metabolites and energy. c Metabolism of low proportion between glutamine and asparagine in CHO-DHFR cell lines. Glutamate was inclined to produce lactate via a truncate TCA cycle

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