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Table 2 Central composite design and response values

From: Improvement of chaetominine production by tryptophan feeding and medium optimization in submerged fermentation of Aspergillus fumigatus CY018

Run Variables Response
(A) Sucrose (g/L) (B) Ammonium acetate (g/L) (C) d-Tryptophan (g/L) CHA production (mg/L)
1 100 3.5 4.283 53.29 ± 1.13
2 100 3.5 4.283 53.92 ± 0.73
3 100 2.66 4.283 46.23 ± 2.51
4 100 3.5 2.603 43.21 ± 0.77
5 66.363 3.5 4.283 44.92 ± 1.16
6 100 3.5 4.283 51.79 ± 2.05
7 100 3.5 4.283 52.82 ± 0.12
8 100 3.5 4.283 53.62 ± 1.71
9 80 3 3.284 43.74 ± 0.95
10 120 4 3.284 57.82 ± 0.21
11 80 4 3.284 43.23 ± 2.55
12 133.634 3.5 4.283 45.38 ± 1.42
13 120 4 5.282 47.83 ± 0.73
14 80 4 5.282 44.93 ± 1.34
15 120 3 5.282 44.94 ± 0.95
16 100 3.5 5.963 45.78 ± 2.11
17 120 3 3.284 39.78 ± 2.76
18 100 4.341 4.283 59.42 ± 0.22
19 80 3 5.282 47.94 ± 0.94
20 100 3.5 4.283 52.86 ± 1.55