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Bioresources and Bioprocessing
Fig. 2 | Bioresources and Bioprocessing

Fig. 2

From: Protein expression analysis of a high-demeclocycline producing strain of Streptomyces aureofaciens and the roles of CtcH and CtcJ in demeclocycline biosynthesis

Fig. 2

Pathway of the β-oxidation of fatty acids, the biosynthetic pathway of demeclocycline (6-DCT) in S. aureofaciens. Black rectangle shows the function of hydroxyacyl-CoA dehydrogenase (CtcH) and the acetyl-CoA generated by the β-oxidation of fatty acids used for the biosynthesis of 6-DCT. Black ellipse shows the function of 6-hydroxylase in the 6-DCT biosynthetic pathway. Abbreviations: PKS, polyketide synthase reaction; 6-CH 3 , 6-methylation reaction; 6-OH, 6-hydroxylation reaction; 7-Cl, 7-chlorination reaction; CoA, coenzyme A; CTC, chlortetracycline; TC, tetracycline; 6-DMT, oxytetracycline

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