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Bioresources and Bioprocessing
Fig. 4 | Bioresources and Bioprocessing

Fig. 4

From: Improved methanol-derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast

Fig. 4

Concentrations of a carbon source and byproducts in the lovastatin feed experiment. a Glucose concentration changes in the medium of strains GS115 and GS-P GAP -tapA with 0, 0.5, or 1.0 mM lovastatin (LV) added. Sterilized glucose (2 mL, 50%) was fed in every 24 h. b Ethanol concentration changes in the medium of strains GS115 and GS-P GAP -tapA with 0, 0.5, or 1.0 mM lovastatin added. c Acetic acid concentration changes in the medium of strains GS115 and GS-P GAP -tapA with 0, 0.5, or 1.0 mM lovastatin added. One milliliter of broth was sampled before and after the glucose feeding to determine the concentrations of glucose, ethanol, and acetate. Three replicates were tested and experiments were conducted two times

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