TY - JOUR AU - Tian, Xiwei AU - Zhou, Gang AU - Wang, Weifei AU - Zhang, Ming AU - Hang, Haifeng AU - Mohsin, Ali AU - Chu, Ju AU - Zhuang, Yingping AU - Zhang, Siliang PY - 2018 DA - 2018/04/30 TI - Application of 8-parallel micro-bioreactor system with non-invasive optical pH and DO biosensor in high-throughput screening of l-lactic acid producing strain JO - Bioresources and Bioprocessing SP - 20 VL - 5 IS - 1 AB - Compared with shake flask, bioreactor offers a relatively stable and controllable extracellular environment for cell growth and metabolism. Meanwhile, parallel micro-bioreactor system could well meet the screening flux requirement in the process of high-throughput strain screening. In this study, a self-developed 8-parallel micro-bioreactor system with non-invasive optical biosensors was introduced to substitute the traditional shake flask. SN - 2197-4365 UR - https://doi.org/10.1186/s40643-018-0207-7 DO - 10.1186/s40643-018-0207-7 ID - Tian2018 ER -