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Bioresources and Bioprocessing

Table 5 Expression of genes involved in transporter mechanisms

From: Transcriptomic analysis of Aspergillus niger strains reveals the mechanism underlying high citric acid productivity

Gene ID (1015)

Gene ID (513.88)

Predicted function (homolog and organism)a

FPKM-10 h

FPKM-40 h

Fold changeb

S1

S3

S2

S1

S3

S2

S1/S3 (10 h)

S1/S2 (10 h)

S1/S3 (40 h)

S1/S2 (40 h)

2.412.1

An02g08970

Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily)

185.2

2.21

94.74

21.26

4.17

5.31

6.38

–

2.44

2.00

3000074

An08g10970

Synaptic vesicle transporter SVOP and related transporters

160.28

0.71

917.73

6.31

9.60

11.21

7.80

− 2.51

–

–

160123

An17g01710

Synaptic vesicle transporter SVOP and related transporters

103.76

2.77

49.29

930.44

2.51

122.66

5.22

1.07

8.53

2.92

5000334

An07g05880

Synaptic vesicle transporter SVOP and related transporters

107.56

4.57

49.04

70.54

8.35

23.06

4.55

1.13

3.07

1.61

5.1708.1

No

Synaptic vesicle transporter SVOP and related transporters

24.18

2.10

58.59

323.21

43.80

63.16

3.52

− 1.27

2.88

2.35

160129

An10g00690

Permease of the major facilitator superfamily

118.95

0.44

26.12

13.04

6.55

0.91

8.07

2.18

–

3.83

9000464

An12g03550

Permease of the major facilitator superfamily

80.14

1.01

28.94

53.88

13.55

1.50

6.29

1.46

1.99

5.16

31842

An08g03200

Ammonia permease

658.74

11.45

452.98

874.63

583.09

67.70

5.84

–

–

3.69

8.781.1

An14g02390

Ammonia permease

95.62

5.25

9.21

6.99

7.80

5.15

4.18

3.37

–

–

150043

No

Amino acid transporters

313.46

3.98

494.76

1872.15

1170.98

219.82

6.30

–

–

3.09

18.284.1

An16g07900

Amino acid transporters

91.62

2.61

2.59

60.14

8.98

12.63

5.13

5.14

2.74

2.25

11.172.1

An09g02550

Amino acid transporters

85.21

1.01

3.44

178.80

4.02

13.43

6.39

4.63

5.47

3.73

19000022

An03g01590

Amino acid transporters

77.90

0.49

6.71

79.07

7.25

1.22

7.32

3.53

3.44

6.01

51440

An07g01950

Xanthine/uracil transporters (A. nidulans, uapC)

103.74

21.22

60.84

245.16

194.55

16.35

2.28

–

–

3.90

31302

An08g06240

Uridine permease/thiamine transporter/allantoin transport

60.46

4.80

28.19

269.89

72.22

3.70

3.65

1.10

1.90

6.18

110148

No

Tetrapeptide transporter, OPT1/isp4

1213.89

6.69

1523.02

1328.97

230.62

666.57

6.18

–

2.52

–

18.109.1

An16g06770

Monocarboxylate transporter

45.49

6.18

11.67

106.08

12.00

24.68

2.87

1.95

3.14

2.10

111102

An09g00660

Oligopeptide transporter OPT superfamily

20.89

0.33

96.18

570.88

25.23

123.98

6.00

− 2.20

4.49

2.20

21.45.1

An12g10320

Fe2+/Zn2+ regulated transporter

111.77

5.31

126.14

2585.52

606.42

499.30

4.39

–

2.09

2.37

10845

An01g03790

Na+: solute symporter

74.05

3.14

53.95

51.89

51.48

2.18

4.56

–

–

4.57

1001002

An01g01950

Mg2+ transporter protein, CorA-like

42.43

0.98

12.76

461.93

187.17

408.91

5.44

1.73

1.30

–

9000143

An12g07730

Ctr Cu2+ transporter

79.63

16.88

94.62

518.01

27.41

58.48

2.23

–

4.24

3.14

22.68.1

An04g09850

git1, Inorganic phosphate transporter

16.87

1.25

20.28

100.07

22.88

14.74

3.75

–

2.12

2.76

240077

An19g00340

Ca2+/H+ antiporter VCX1 and related proteins

50.22

0.86

15.81

615.05

81.96

175.32

5.77

1.58

2.98

1.89

240035

An19g00330

Ca2+/H+ antiporter VCX1 and related proteins

29.77

2.50

15.81

204.99

28.69

92.59

3.57

–

2.83

1.15

  1. “–” denotes genes with no differences at transcriptional level, fold change ≤ 1. Some of the genes have small differences, but have a decisive impact on CA production. We also used fold change as an indicator
  2. “No” denotes that sequence was not mapped to the genome sequence assembly of A. niger strain CBS 513.88
  3. a Description of gene or closest homolog (BLASTP)
  4. b Fold change of differentially expressed (FDR < 0.05, FPKM ≥ 50 in A. niger YX-1217 at time 10 or time 40) genes based on a comparison of transcription levels at YX-1217/ATCC 1015 (designated as S1/S3) (10 h), YX-1217/YX-1217G (designated as S1/S2) (10 h), YX-1217/ATCC 1015 (designated as S1/S3) (40 h), and YX-1217/YX-1217G (designated as S1/S2) (40 h), respectively
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