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Fig. 1 | Bioresources and Bioprocessing

Fig. 1

From: 2-Hydroxy-4-(3′-oxo-3′H-benzofuran-2′-yliden)but-2-enoic acid biosynthesis from dibenzofuran using lateral dioxygenation in a Pseudomonas putida strain B6-2 (DSM 28064)

Fig. 1

Benzofuran derivatives that are pharmacological agents and products of the DBF biodegradation pathway. a Compounds with biological activities used in pharmacology. (1) 4-Hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester showed selective and potent cytotoxicity against tumors (Hayakawa et al. 2004a, b). (2) Compound 2 was found to be the most potent anti-inflammatory agent (Ma et al. 2016). (3) RO-09-4609 is a basic antifungal agent (Nevagi et al. 2015). (4) Hit compound 4 has a high therapeutic index in HIV inhibition (Khanam and Shamsuzzaman 2015). b HOBB (a benzofuran derivative) is the main product of DBF catalysis by BphA, BphB, and BphC in the lateral degradation pathway of Pseudomonas putida strain B6-2

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