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Bioresources and Bioprocessing

Table 1 Effect of uridine on cell growth and mAb production

From: Uridine modulates monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch cultures

Cultures with different feed medium

Peak VCD (×106 cells/mL)

IVCC (109 cells day/L)

Mab concentration (g/L)

qmAb [mg/(109 cells day)]

Control

12.13

98.98

2.25

22.72

Uridine added

15.90**

148.64 **

3.69 **

24.81

  1. IVCC integral of viable cell concentration with time, qmAb specific mAb production
  2. * p < 0.05 relative to control; ** p < 0.01 relative to control
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