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Table 8 Comparison of supercritical-CO2 extraction with solvent extraction.

From: Integration of biology, ecology and engineering for sustainable algal-based biofuel and bioproduct biorefinery

Solvent extraction

Supercritical CO2 extraction

References

Procedure uses expensive/toxic organic solvents. Therefore, energy-intensive solvent removal operations are needed

Procedure use non-toxic/inexpensive CO2 as a solvent. Extra unit operations are not needed

Sahena et al. (2009)

Polar substances get dissolved along with the lipophilic substances from the raw material due to poor selectivity of the solvent. During solvent removal operations, these polar substances form polymers, which lead to discoloration of the extract

No such possibility exists since CO2 is highly selective and no chance of polar substances forming polymers exists

Sahena et al. (2009)

When non-polar organic solvents is used, only limited amount of neutral lipids can be extracted. When non-polar/polar organic solvent mixture is used, both neutral lipids and polar lipids are extracted

The polarity of SC-CO2 can be varied by employing polar co-solvents

Halim et al. (2012)

Requires little energy as ambient conditions are carried out

Energy intensive due to heating (T > Tc) and compression (P > Pc) requirement for CO2 supercritical state

Halim et al. (2012)