TY - JOUR AU - Liu, Ting AU - Bessembayeva, Lyailya AU - Chen, Jun AU - Wei, Liu-Jing AU - Hua, Qiang PY - 2019 DA - 2019/01/03 TI - Development of an economical fermentation platform for enhanced ansamitocin P-3 production in Actinosynnema pretiosum JO - Bioresources and Bioprocessing SP - 1 VL - 6 IS - 1 AB - Ansamitocin P-3 (AP-3), produced by Actinosynnema pretiosum, has extraordinary antitumor activity and has been used as toxic “warhead” in antibody-conjugated drugs. However, AP-3 production is limited by its low yield and thus the high cost of fermentation. In this study, we aimed to reduce fermentation costs by utilizing the low-cost substrates and improve the AP-3 production, simultaneously. SN - 2197-4365 UR - https://doi.org/10.1186/s40643-018-0235-3 DO - 10.1186/s40643-018-0235-3 ID - Liu2019 ER -