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Bioresources and Bioprocessing

Table 4 Summary of improvements in AP-3 production in this study

From: Development of an economical fermentation platform for enhanced ansamitocin P-3 production in Actinosynnema pretiosum

Conditions AP-3 (mg/L) Fold change
30 g/L CM 0.0 ± 0.02 0
30 g/L CM + YE 9.3 ± 0.7 1
Opt mediuma 111.9 ± 0.9 12
Opt + isbb 120.4 ± 2.2 13
Opt + SbO + B1 + isbc 141.4 ± 2.9 15
  1. aOpt medium, optimized medium with 63.22 g/L cane molasses, 22.92 g/L glycerol, 3.29 g/L soybean powder
  2. bOpt + isb, 18 mM isobutanol was added to optimized medium on day 3
  3. cOpt + SbO + B1 + isb, soybean oil and vitamin B1 were added to optimized medium at final concentrations of 4 g/L and 200 mg/L, respectively, and 18 mM isobutanol was added
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