Bioresources and Bioprocessing

Table 3 Inhibition zone radius of M4018 and M4018 Δrim

From: Study on a two-component signal transduction system RimA1A2 that negatively regulates oxytetracycline biosynthesis in Streptomyces rimosus M4018

Antibiotics	Inhibitory zone radius/mm
Antibiotics	M4018	M4018 Δrim
OTC (mg/ml)
20	10.33 ± 0.58	9.33 ± 0.58
50	15.67 ± 1.15	13.67 ± 1.15
Kan (mg/ml)
2.5	11.33 ± 0.58	8.67 ± 0.58
10	16.67 ± 1.15	12.33 ± 1.15
25	19.67 ± 1.53	15.00 ± 1.00
Cef (mg/ml)
2.5	–	–
10	6.00 ± 1.00	6.33 ± 0.58
25	12.00 ± 0.00	11.67 ± 1.53
Ery (mg/ml)
2.5	15.67 ± 1.15	16.00 ± 1.73
10	18.00 ± 1.00	17.33 ± 1.15
25	21.00 ± 1.00	20.33 ± 1.25
Amp (mg/ml)
2.5	–	–
10	8.67 ± 1.53	8.67 ± 0.58
25	12.67 ± 0.58	12.33 ± 1.15
Chl (mg/ml)
0.25	17.67 ± 0.58	14.33 ± 1.15
0.5	21.00 ± 1.00	17.00 ± 0.00
1	25.33 ± 0.58	20.00 ± 1.73
Rifa (mg/ml)
2.5	17.67 ± 0.58	17.33 ± 1.53
10	20.67 ± 1.15	19.00 ± 1.00
25	21.67 ± 1.53	21.33 ± 1.53

Numbers in italic represent significant increase in radius of inhibitory zone under the same experimental conditions. M4018: the parental strain, M4018 Δrim: the rimA1-disrupted mutant derived from M4018; the antibiotics used in the study include oxytetracycline (OTC), kanamycin (Kan), cefotaxime (Cef), erythromycin (Ery), ampicillin (Amp), chloramphenicol (Chl) and rifamycin (Rifa)

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