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Table 5 Studies related to chitosan blends and their application

From: Seafood waste: a source for preparation of commercially employable chitin/chitosan materials

S. no Scaffold Host and targeted defects Outcomes References
1 Chitosan + COG + PLGA Skin defects in rats Superior healing and greater expression of IHC, higher mechanical properties Wang et al. (2013)
2 Chitosan membrane + COG Human skin defects Enhanced regeneration of skin wounds after 14 days Sarkar et al. (2013)
3 Chitosan + silk fibroin Sciatic nerve defects of adult Sprague–Dawley rats Better nerve tissue regeneration Gu et al. (2014)
4 Chitosan + gelatin Skin injuries of rabbit Adequate cytocompatibility in vitro, inflammation was exhibited in vivo Han et al. (2014)
5 Chitosan + cellulose + silver nanoparticles Skin injuries in the backs of Wistar rats Efficient in the regeneration of skin wounds Ahamed et al. (2015)
6 Chitosan + silk fibroin + HAP Subcutaneous tissue of 6–8-week-old rat Induced osteogenic differentiation Shalumon et al. (2015)
7 Chitosan + gelatin Subcutaneous tissue of mice Enhanced bone-like tissue formation Ji et al. (2015)
8 Chitosan sponges + copper Calvarial defects in rats Augmented bone neoformation D’Mello et al. (2015)
9 Chitosan + alginate subcutaneous tissue of mice Boosted osteogenic differentiation Caridade et al. (2015)
10 Chitosan + citric acid tibial defects of rabbits Prompted bone regeneration and adequate cytocompatibility Ghosh et al. (2015)
11 COG + chitosan + PLGA + polyurethane implantation in skin lesions on the backs of 2-month-old Sprague–Dawley rats Improved regeneration of cutaneous tissue wounds and better mechanical performance Wang et al. (2016)
12 Chitosan + COG + HAP Implanted in calvarial defects of 6-week-old mice Efficient bone regeneration and repairing of defects Xie et al. (2016)