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Bioresources and Bioprocessing
Fig. 4 | Bioresources and Bioprocessing

Fig. 4

From: Cooperation of FGF/MEK/ERK and Wnt/β-catenin pathway regulators to promote the proliferation and pluripotency of mouse embryonic stem cells in serum- and feeder-free conditions

Fig. 4

Synergism of FGF/MEK/ERK signaling and Wnt/β-catenin signaling in maintaining mESC proliferation. The concentration of SB216763, SU5402 and PD0325901 used here was 5 μM, 2 μM and 1 μM. A Comparison of fold expansion in each passage. B Fold expansion of total cells after three passages. Group a (no treatment), Group b (SB216763), Group c (PD0325901 + SU5402), Group d (PD0325901 + SU5402 + SB216763). Error bars are standard deviations (n = 3). *Represents significant difference (P < 0.05)

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