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Table 1 Guide and target preferences of characterized pAgo proteins

From: Characterization of a recombinant thermotolerant argonaute protein as an endonuclease by broad guide utilization

pAgo proteins

Guide information

Activity

References

Host

Argonaute name

Guide

5′-end nucleotide preference

RNA-guided RNA interference

RNA-guided DNA interference

DNA-guided RNA interference

DNA-guided DNA interference

Methanocaldococcus jannaschii

MjAgo

DNA

5′-P

+

Zander et al. (2014)

Rhodobacter sphaeroides

RsAgo

RNA

5′-P

+

Olovnikov et al. (2013)

Aquifex aeolicus

AaAgo

DNA

5′-P

+

Yuan et al. (2005)

Marinitoga piezophila

MpAgo

RNA

5′-OH

+

+

Kaya et al. (2016)

Thermotoga profunda

TpAgo

RNA

5′-OH

+

Kaya et al. (2016)

Thermus thermophilus

TtAgo

DNA

5′-P

+

+

Wang et al. (2008a)

Pyrococcus furiosus

PfAgo

DNA

5′-P

+

Swarts et al. (2015a)