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Table 2 Comparison of intracellular metabolite concentrations (µmol/g DCW) from cultures in control (ck) and mode 8 treatments at different times

From: Enhanced lincomycin A production by calcium gluconate feeding in fermentation of Streptomyces lincolnensis

Metabolite

24 h

48 h

72 h

96 h

120 h

144 h

168 h

ck

Mode 8

ck

Mode 8

ck

Mode 8

ck

Mode 8

ck

Mode 8

ck

Mode 8

ck

Mode 8

Glucose

141.3

119.8

34

29.9

20

23.2

10.7

18.5

13.6

13

13.3

3.5*

4.1

0.6*

Succinate

2.7

1.6

11.8

13

0.4

0.7

7.0

9.3

8.3

11.1

26

0.4*

2.8

15*

Fumarate

22.4

2.1*

9.8

10.6

1.8

1.9

9.3

10.8

5.7

14.7

6.7

1.0*

1.2

27.8*

Malate

0.4

0.37

0.5

0.8

0.5

0.3

< 0.1

2.8

2.7

12.8

7.2

0.9*

0.7

2.8*

α-KG

3.7

1.7

63.9

51.3

2.2

1.5

48.2

12.8

51.9

18.8

67.2

4.2*

68

120.4*

G6P

ND

ND

ND

ND

ND

ND

ND

ND

ND

< 0.1

ND

< 0.1

ND

< 0.1

R5P

ND

ND

ND

ND

ND

ND

ND

ND

ND

< 0.1

ND

< 0.1

ND

< 0.1

S7P

ND

ND

ND

ND

ND

ND

ND

ND

ND

< 0.1

ND

< 0.1

ND

< 0.1

  1. ND represents undetectable; “< 0.1” represents the concentration is lower than the detection limits of 0.1 µmol/g DCW
  2. * Represents p < 0.05