TY - JOUR AU - Tong, Wei AU - Huang, Qun AU - Li, Min AU - Wang, Jian-bo PY - 2019 DA - 2019/11/22 TI - Enzyme-catalyzed C–F bond formation and cleavage JO - Bioresources and Bioprocessing SP - 46 VL - 6 IS - 1 AB - Organofluorines are widely used in a variety of applications, ranging from pharmaceuticals to pesticides and advanced materials. The widespread use of organofluorines also leads to its accumulation in the environment, and two major questions arise: how to synthesize and how to degrade this type of compound effectively? In contrast to a considerable number of easy-access chemical methods, milder and more effective enzymatic methods remain to be developed. In this review, we present recent progress on enzyme-catalyzed C–F bond formation and cleavage, focused on describing C–F bond formation enabled by fluorinase and C–F bond cleavage catalyzed by oxidase, reductase, deaminase, and dehalogenase. SN - 2197-4365 UR - https://doi.org/10.1186/s40643-019-0280-6 DO - 10.1186/s40643-019-0280-6 ID - Tong2019 ER -