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Fig. 5 | Bioresources and Bioprocessing

Fig. 5

From: Metabolic pathway analysis for in silico design of efficient autotrophic production of advanced biofuels

Fig. 5

Phenotypic space of C. necator H16 mutants designed by elementary mode analysis for high yield of isobutanol (a) and hexadecanol (b). Each black circle represents individual pathways in which a linear combination of all pathways forms possible phenotypes existing in the designed mutant with yields shown in colored surface plot. The x and y axes are uptake rate for H2 and CO2 of each pathway relative to its total gas uptake. Dashed lines show phenotypic space of the designed mutant under controlled gas input composition at fractional H2 input (fqH2) > 0.67. After the in silico multiple gene deletions, predicted yield space (presented as colored surface plot) was higher compared to that by the wild-type in Fig. 3

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