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Fig. 1 | Bioresources and Bioprocessing

Fig. 1

From: Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing

Fig. 1

a Viable cell density (VCD) and b cell viability profiles for the batch N-1 seed at 200-L scale for Process B and the perfusion N-1 seed at 200-L scale for Process C; c VCD; d cell viability; e normalized titer, and f in-process quality attribute profiles on Day 14 at harvest for the subsequent fed-batch cell culture performance using Process B in 1000-L bioreactors and Process C in 500-L bioreactors for mAb1 production. The maximum titer on Day 14 for Process C at 500-L scale was normalized as 1 for mAb1. Process B values are reported as average ± standard deviation (n = 5), while Process C values are reported as average ± difference/2 (n = 2)

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