Skip to main content
Bioresources and Bioprocessing
Fig. 4 | Bioresources and Bioprocessing

Fig. 4

From: Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing

Fig. 4

a Viable cell density (VCD); b cell viability; c normalized titer, and d in-process quality attribute profiles on Day 14 at harvest for the subsequent fed-batch cell culture performance using Process B in 1000-L bioreactors and Process C in 500-L bioreactors for mAb3 production. The maximum titer on Day 14 for Process C at 500-L scale was normalized as 1 for mAb3. Most of the Process B values are reported as average ± standard deviation (n = 3) except that quality attributes are reported as average ± difference/2 (n = 2) because only two Day 14 samples were available for in-process quality assays, while Process C values are reported as average ± difference/2 (n = 2)

Back to article page