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Bioresources and Bioprocessing
Fig. 2 | Bioresources and Bioprocessing

Fig. 2

From: Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process

Fig. 2

Score plot: The score plot given in this figure is a direct result from the batch evolution model (BEM) that SIMCA analyzes. It shows that each of the reactors from each condition appears to group together on the score plot. This indicates high similarity between each bioreactor in a given condition which would be expected. Furthermore, from this score plot, it is apparent that with the addition of amino acids there is a distinct improvement in titer. This is apparent from the coloration of each data point (representing each reactor) where a bluish color indicates low titer and a reddish color indicates high titer. When comparing the first group of reactors (green circle with V201, V202, and V203) with the second group of reactors (purple circle with V204 and V205), it is possible to see that the titer of the first group is lower than that of the second group which indicates that the addition of 4 amino acids to the bioreactor cultivation had a positive impact on titer

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