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Bioresources and Bioprocessing
Fig. 3 | Bioresources and Bioprocessing

Fig. 3

From: Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process

Fig. 3

VIP Plot and Correlation Heat Map generated from BLM model (R2X (cum) = 0.635, R2Y (cum) = 0.992, and Q (cum) = 0.957). The VIP plot generated from the BLM model using a PLS approach includes all the metabolites analyzed in the study (c). For simplicity, a cut-away of the VIP plot displays the top 10 metabolites in closer detail (a). A correlation matrix in the form of a heat map (b) displays the relative metabolite correlations to titer as positive (green) or negative (red). Highlighted in boxes are the locations of the top ten metabolites identified from the VIP plot

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