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Table 4 KEGG pathway analysis summary

From: Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process

Gene

Description

Fold change (p value)

Gly, Ser, Thr metabolism

 Sdsl

N-Sulphoglucosamine sulphohydrolase 1

+1.89 (7.31E − 3)

Tyrosine metabolism

 Fadh1

Acylpyruvase FAHD1, mitochondrial

+9 (9.47E − 3)

 Fah

Fumarylacetoacetase isoform X3

+5.54 (8.95E − 34)

Lysine degradation

 Echs1a,b

Enoyl-CoA hydratase 1

+6.08 (8.22E − 9)

 Ogdhc

2-oxoglutarate dehydrogenase

+3.02 (1.48E − 56)

 Hadha,b

Hydroxyacyl-coenzyme A dehydrogenase

+1.96 (6.31E − 13)

 Gcdha

Glutaryl-CoA dehydrogenase

+1.28 (1.11E − 1)

TCA cycle

 Pck2

Phosphoenolpyruvate carboxykinase 2

+3.09 (3.84E − 10)

 Pdhb

Pyruvate dehydrogenase

+1.75 (1.43E − 6)

 Dlat

Dihydrolipoamide S-acetyltransferase

+1.13 (1.91E − 1)

Fatty acid metabolism/degradation

 Oxsmb

3-oxoacyl-ACP synthase

+3.44 (1.28E − 5)

 Acadsba

acyl-CoA dehydrogenase

+1.44 (1.02E − 3)

  1. aGenes also involved in fatty acid degradation pathway
  2. bGenes also involved in fatty acid metabolism
  3. cGenes also involved in TCA cycle. Fold change values included here only represent differentially expressed genes in V205, the highest titer condition overall