TY - JOUR AU - Qiao, Lijia AU - Li, Xiaobo AU - Ke, Xiang AU - Chu, Ju PY - 2020 DA - 2020/03/06 TI - A two-component system gene SACE_0101 regulates copper homeostasis in Saccharopolyspora erythraea JO - Bioresources and Bioprocessing SP - 12 VL - 7 IS - 1 AB - Saccharopolyspora erythraea (S. erythraea) is a Gram-positive bacterium widely used for the production of erythromycin, a potent macrolide antibiotic. However, the mechanism behind erythromycin production is poorly understood. In the high erythromycin-producer strain S. erythraea HL3168 E3, the level of copper ions positively correlates with erythromycin production. To explain this correlation, we performed a genome-based comparison between the wild-type strain NRRL23338 and the mutant strain HL3168 E3, and further characterized the identified gene(s) by targeted genome editing, mRNA transcript analysis, and functional analysis. SN - 2197-4365 UR - https://doi.org/10.1186/s40643-020-0299-8 DO - 10.1186/s40643-020-0299-8 ID - Qiao2020 ER -