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Table 1 Parameters and levels used in the central composite design (CCD)

From: Modeling bikaverin production by Fusarium oxysporum CCT7620 in shake flask cultures

Independent variables

Symbol

Coded levels

− 1.68

− 1

0

+ 1

+ 1.68

Temperature (°C)

T

21

24

28

32

35

Agitation speed (rpm)

A

71

115

180

245

289

Rice concentration (g/L)

[S]

16.4

30

50

70

83.6