Table 1 Synthesis of chiral alcohols catalyzed by LkADH or LkADH and CbADH-6M
From: Computational design of highly stable and soluble alcohol dehydrogenase for NADPH regeneration
Entry | Substrate | Relative activity (%) | Product | ee (%) | Conversion rate (%) | |
|---|---|---|---|---|---|---|
LkADH | LkADH and CbADH-6M | |||||
1 |
| 100 |
| (S) > 99 | 94.6 | 99.5 |
2 |
| 70 |
| (S) > 99 | 80.3 | 99.5 |
3 |
| 92 |
| (S) > 99 | 92.5 | 99.5 |
4 |
| 84 |
| (S) > 99 | 86.1 | 99.5 |
5 |
| 59 |
| (S) > 99 | 76.1 | 90.8 |
