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Table 1 Bioreactors used in this study for BHK-21 cell cultivation

From: A novel scale-up strategy for cultivation of BHK-21 cells based on similar hydrodynamic environments in the bioreactors

Bioreactor typea 5L-EE-0.45 5L-EE-0.5 5L-PBT-0.5 42L-EE-0.37 350L-EE-0.5 1000L-EE-0.5
Tank volume (L) 5 5 5 42 350 1000
Tank diameter (mm) 192 192 192 290 644 914
Impeller diameter (mm) 86.4 96.0 96.0 108.0 323.5 429.7
Impeller diameter/tank diameter 0.45 0.50 0.50 0.37 0.50 0.50
Culture level height (mm) 158.0 158.0 158.0 492.5 737.6 1067.6
Load volume (L) 3.50 3.50 3.50 31.0 238.0 682.0
Impeller type EE EE PBT EE EE EE
Number of impellers Single Single Single Single Double Double
  1. aBioreactor type is expressed as “bioreactor volume-impeller type-ratio of impeller diameter to tank diameter”