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Bioresources and Bioprocessing
Fig. 1 | Bioresources and Bioprocessing

Fig. 1

From: Targeted accumulation of selective anticancer depsipeptides by reconstructing the precursor supply in the neoantimycin biosynthetic pathway

Fig. 1

The gene organization of the NAT biosynthetic gene cluster (nat BGC) (a) and the biosynthetic routes of the starting precursor for the NAT NRPS-PKS assembly line (b). The genes and related products of natH-L and natO are marked in green and blue, respectively. The bio-reaction schemes of 3-hydroxybenzoate (3-HBA) generation and loading processes are highlighted in red. The dashed arrow represents that anthranilate could be produced from chorismic acid via primary aromatic amino acid metabolism. A: adenylation; T: thiolation or acyl-carrier protein; C: condensation; KR: ketoreductase; KS: ketosynthase; AT: acyltransferase; MT: methyltransferase; TE: thioesterase

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