Fig. 18
From: Mining methods and typical structural mechanisms of terpene cyclases
a Products of AtCPS and its mutants. b Superposition of ent-copalyl diphosphate synthase from Arabidopsis thaliana (AtCPS) in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate (PDB ID: 4LIX, yellow) and ent-copalyl diphosphate synthase from Streptomyces platensis (SpCPS) (PDB ID: 5BP8, blue). c Active sites of AtCPS in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate (PDB ID: 3PYA). d Active sites of AtCPS in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate (PDB ID: 4LIX). The substrate analogues and DXDD motif are shown in sticks