Fig. 6

Co-factors for methyltransferase reaction. a Illustration of SAM regeneration reactions. b Illustration of SAM analogues. c K_i of SAH and the K_m of SAM for small molecule methyltransferases display a high correlation with spearman coefficient of 0.86 (refer to Table 3 for detailed information). The abbreviations are as follows. SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; Met, l-methionine; Hcy, hmocysteine; SRH, S-(5-deoxy-d-ribos-5-yl)-l-homocysteine; THF, Tetrahydrofolate; THPG, tetrahydropteroyltri-l-glutamate; H3C-THF, 5-methyltetrahydrofolate; H3C-THPG, 5-methyltetrahydropteroyltri-l-glutamate; SAE,S-adenosyl-l-ethionine; SAA, S-allyl-l-homocysteine; SAP, S-propyl-l-homocysteine; l-^tMet, tetrazole-l-methionine; ^7dzATP, 7-deaza-ATP; Pi, phosphate; PPi, pyrophosphate; MT, methyltransferase; HMT, halide methyltransferase; SAHH, SAH hydroxylase; Mtn, SAH nucleosidase; LuxS, S-ribosylhomocysteine lyase; metH, cobalamin (or viatamin B12)-dependent methionine synthase; metE, cobalamin (or viatamin B12)-independent methionine synthase; BHMT, Betaine–homocysteine S-methyltransferase 1; BHMT2, S-methylmethionine–homocysteine S-methyltransferase; ADK, adenosine kinase; PPK2-I/II, polyphosphate kinase; metK, S-adenosylmethionine synthase