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Table 3 Summary of Km,SAM and Ki,SAH of all the small molecule methyltransferase in BRENDA

From: Biotechnological applications of S-adenosyl-methionine-dependent methyltransferases for natural products biosynthesis and diversification

EC number

Name

Organism

Km (µM SAM)

Ki (µM SAH)

Refs.

2.1.1.6

Catechol O-methyltransferase

Homo sapiens

3.1

1

Rivett and Roth (1982)

2.1.1.6

Catechol O-methyltransferase

Candida tropicalis

6.2

6.9

Veser (1987)

2.1.1.15

Fatty-acid O-methyltransferase

Mycobacterium marinum

33.6a

0.7a

Petronikolou and Nair (2015)

2.1.1.20

Glycine N-methyltransferase

Oryctolagus cuniculus

200

30

Kloor et al. (2004)

2.1.1.79

Cyclopropane-fatty-acyl-phospholipid synthase

Escherichia coli

90

220

Taylor and Cronan (1979)

2.1.1.95

Tocopherol C-methyltransferase

Arabidopsis thaliana

5.2

4uMb

Koch et al. (2003)

2.1.1.106

Tryptophan 2-C-methyltransferase

Streptomyces laurentii

120

480

Frenzel et al. (1990)

2.1.1.142

Cycloartenol 24-C-methyltransferase

Glycine max

32

56

Nes et al. (2003)

2.1.1.156

Glycine/sarcosine N-methyltransferase

Halorhodospira halochloris

280 with sarcosine

400c

Nyyssölä et al. (2001)

420 with glycin

500c

2.1.1.156

Glycine/sarcosine N-methyltransferase

Aphanothece halophytica

700 with glycin

500

Waditee et al. (2003)

600 with sarcosine

300

Ectothiorhodospira halochloris

420 with glycin

500

280 with sarcosine

400

Rat

36 with glycin

80

2.1.1.157

Sarcosine/dimethylglycine N-methyltransferase

Aphanothece halophytica

180

600

Waditee et al. (2003)

Ectothiorhodospira halochloris

210 with sarcosine

500

2.1.1.165

Methyl halide transferase

Brassica oleracea

30

32

Attieh et al. (1995)

2.1.1.7

Nicotinate N-methyltransferase

Glycine max

55

95

Upmeier et al. (1988)

2.1.1.8

Histamine N-methyltransferase

Human

1.8

1.1

Francis et al. (1980)

2.1.1.9

Thiol S-methyltransferase

Rat

105

144

Borchardt and Cheng (1978)

2.1.1.25

Phenol O-methyltransferase

Phanerochaete chrysosporium

99

41

Coulter et al. (1993)

2.1.1.46

Isoflavone 4′-O-methyltransferase

Cicer arietinum

80

30

Wengenmayer et al. (1974)

2.1.1.50

Loganate O-methyltransferase

Catharanthus roseus

742.1

400

Murata et al. (2008)

2.1.1.53

Putrescine N-methyltransferase

Datura stramonium L.

100

10

Walton et al. (1994)

2.1.1.53

Putrescine N-methyltransferase

Hyoscyamus albus

227

110

Hibi et al. (1992)

2.1.1.67

Thiopurine S-methyltransferase

Homo sapiens

2.7

0.75

Woodson and Weinshilboum (1983)

2.1.1.68

Caffeate O-methyltransferase

Beta vulgaris L.

13

4

Poulton and Butt (1975)

2.1.1.68

Caffeate O-methyltransferase

Glycine max

15

6.9

Poulton et al. (1976)

2.1.1.68

Caffeate O-methyltransferase

Medicago sativa L.

7

2

Edwards and Dixon (1991)

2.1.1.68

Caffeate O-methyltransferase

Medicago sativa L.

12

4

Edwards and Dixon (1991)

2.1.1.91

Isobutyraldoxime O-methyltransferase

Pseudomonas sp. N.C.I.B. 11652

150

27

Harper and Kennedy (1985)

2.1.1.94

Tabersonine 16-O-methyltransferase

Catharanthus roseus

21.7

6

Levac et al. (2008)

2.1.1.102

Demethylmacrocin O-methyltransferase

Streptomyces fradiae

110

226

Kreuzman et al. (1988)

2.1.1.104

Caffeoyl-CoA O-methyltransferase

Petroselinum crispum

8.2

3.5

Pakusch and Matern (1991)

2.1.1.103

Phosphoethanolamine N-methyltransferase

Caenorhabditis elegans

145

9.1

Brendza et al. (2007)

2.1.1.103

Phosphoethanolamine N-methyltransferase

Plasmodium falciparum

153

50c

Pessi et al. (2004)

2.1.1.107

Uroporphyrinogen-III C-methyltransferase

Pseudomonas denitrificans

6.3

0.32

Blanche et al. (1989)

2.1..1.136

Chlorophenol O-methyltransferase

Trichoderma longibrachiatum

284

368.9

Coque et al. (2003)

2.1.1.140

(S)-Coclaurine-N-methyltransferase

Tinospora cordifolia

40

62

Loeffler et al. (1995)

2.1.1.147

Corydaline synthase

Corydalis cava

2.7

2.6

Rueffer et al. (1994)

2.1.1.153

Vitexin 2″-O-rhamnoside 7-O-methyltransferase

Avena sativa L.

1.6

2.5

Knogge and Weissenböck (1984)

2.1.1.154

Isoliquiritigenin 2′-O-methyltransferase

Medicago sativa L.

17.7

2.2

(Medicago sativa L.) Maxwell et al. (1992)

2.1.1.273

Benzoate O-methyltransferase

Antirrhinum majus

28

7

Murfitt et al. (2000)

2.1.1.338

Desmethylxanthohumol 6′-O-methyltransferase

Humulus lupulus

286

98

Nagel et al. (2008)

2.1.1.343

8-Amino-8-demethylriboflavin N,N-dimethyltransferase

Streptomyces davaonensis

70

27

Tongsook et al. (2016)

  1. aKd
  2. bConcentration when inhibition observed
  3. cIC50 or 50% inhibition