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Table 1 The screened top 20 differential metabolites of engineered B. subtilis and E. coli during co-fermentation

From: A novel strategy for D-psicose and lipase co-production using a co-culture system of engineered Bacillus subtilis and Escherichia coli and bioprocess analysis using metabolomics

Differential metabolitesa 1 vs5 3 vs5 2 vs6 4 vs6
1 Choline L-Proline L-Proline L-Proline
2 Adenine Morusin Choline Choline
3 Turanose Choline Adenine 7,8-Dihydro-3b,6a-dihydroxy-alpha-ionol 9-glucoside
4 L-Histidine Cellobiose L-Histidine 1-Pyrroline
5 Isopropylpyrazine 7,8-Dihydro-3b,6a-dihydroxy-alpha-ionol 9-glucoside 2,5-Dihydro-2,4,5-trimethyloxazole T2 Triol
6 Niacinamide 1-Pyrroline Niacinamide Protoanemonin
7 Gerberinol T2 Triol Gerberinol Beta-Carboline
8 1H-Indole-3-carboxaldehyde Protoanemonin 2,6-Diaminohexanoic acid 3-Methyladenine
9 Cytidine monophosphate 5H-Cyclopentapyrazine 1H-Indole-3-carboxaldehyde Trimethylpyrazine
10 gamma-Aminobutyric acid Beta-Carboline L-Gulose Dictyoquinazol C
11 N-Acetylcadaverine Trehalose Cytidine monophosphate 2-Ethyl-6-methylpyrazine
12 Histamine 4-Aminophenol gamma-Aminobutyric acid 2-Methyl-3-propylpyrazine
13 N-Methylcalystegine B2 Turanose N-Acetylcadaverine 2,5-Dihydro-2,4,5-trimethyloxazole
14 L-Histidinol 3-Methyladenine Histamine Adenosine
15 2'-O-Methyladenosine (1S,2S,4R)-1,8-Epoxy-p-menthan-2-ol glucoside N-Methylcalystegine B2 2,5-Dihydro-2,4-dimethyloxazole
16 Indoleacetaldehyde Trimethylpyrazine ( +)-2,3-Dihydro-3-methyl-1H-pyrrole Niacinamide
17 Levan Dictyoquinazol C Methenamine Gerberinol
18 1-Pyrroline-5-carboxylic acid 2-Ethyl-6-methylpyrazine gamma-Glutamyltyrosine beta-Alanine
19 Alanyl-proline 2-Methyl-3-propylpyrazine 2'-O-Methyladenosine 4-Hydroxy-2-butenoic acid gamma-lactone
20 (Â ±)-2-Methylthiazolidine 2,5-Dihydro-2,4,5-trimethyloxazole L-Pipecolic acid 2-[(5-Methylsulfinyl)-4-penten-2-ynylidene]-1,6-dioxaspiro[4.4]non-3-ene
  1. aThe card value standard for screening differential metabolites is p < 0.05 and VIP > 1.0