Fig. 1
From: Advances in engineering microbial biosynthesis of aromatic compounds and related compounds
The aromatic amino acid biosynthesis pathway illustrated with several examples of engineered microbial products. Precursor molecules of erythrose-4-phosphate (E4P) and phosphoenolpyruvate (PEP) are shown in blue. Shikimate pathway metabolites are shown in red with abbreviations as follows: DAHP deoxy-d-arabinoheptulosonate 7-phosphate, DHQ 3-dehydroquinate, DHS 3-dehydroshikimate; SHK shikimate, S3P shikimate 3-phosphate, EPS 5-enolpyruvylshikimate-3-phosphate, CHM chorismate. Orange metabolites are native to non-auxotrophic microbes downstream of the chorismate branch point in aromatic amino acid biosynthesis. A representative sampling of metabolites that are non-native to most microbes but have been overproduced as a result of engineered heterologous expression are shown in green. Abbreviations used here are amino-Phe (4-amino-l-phenylalanine), DOPA (l-dihydroxyphenylalanine), and 5-hydroxy-Trp (5-hydroxy-l-tryptophan)