Fig. 2
From: Recent advances in the microbial synthesis of lactate-based copolymer
Synthetic pathway of PHA with various compositions in recombinant E. coli. Dotted arrows represent simplified metabolic processes. Letters in boxes indicate enzymes. Pct propionyl-CoA transferase, Bct butyryl-CoA transferase, PhaA β-ketothiolase, PhaB NADPH-dependent acetoacetyl-CoA reductase, PhaC PHA synthase, Ldh lactate dehydrogenase, CimA citramalate synthase, LeuB 3-isopropylmalate dehydrogenase, LeuCD isopropyl malate (IPM) isomerase, PanE 2HB dehydrogenase, PrpE propionyl-CoA synthetase, PDHc pyruvate dehydrogenase complex, IlvA l-threonine dehydratase, SucD succinate semialdehyde dehydrogenase, 4HbD 4HB dehydrogenase, OrfZ CoA transferase, XylB xylose dehydrogenase, XylC xylonolactonase, AceA isocitrate lyase, AceK isocitrate dehydrogenase kinase/phosphatase, YcdW glyoxylate reductase, XylA xylose isomerase, Dte d-tagatose 3-epimerase, FucK ribulose kinase, FucA aldolase, AldA aldehyde dehydrogenase, IlvBNmut mutant acetolactate synthase, AlsS acetolactate synthase, IlvC ketol-acid reductoisomerase, IlvD dihydroxyacid dehydratase, DhaB glycerol dehydratase, DhaT 1,3-propanediol dehydrogenase, AldD aldehyde dehydrogenase, Pcs′ ACS domain of tri-functional propionyl-CoA synthetase, PduP propionaldehyde dehydrogenase, PhaJ4 (R)-specific enoyl-CoA hydratase 4