Fig. 2

Cellulase regulation at the transcription level. In T. reesei, transcription of cellulase is under complicated and coordinated regulation networks including transcription factors, signal transduction, chromatin status, secondary metabolism and environmental factors such as light, nitrogen source, pH and metal ion, which are depicted in different areas with diverse colors. Only the factors involved in the crosstalk with other factors and pathways are depicted in the picture. The inter-regulation of different factors and regulators is shown by black arrows and lines. The dashed lines indicate characterized regulation mechanism in other fungi but not in T. reesei