Skip to main content
Fig. 5 | Bioresources and Bioprocessing

Fig. 5

From: Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model

Fig. 5

Proteomic differences between cells in 2D monolayer and 3D MTS. a Heatmap of differential proteins between 2D monolayer and 3D MTS. 50 differential proteins in the top KEGG pathways (sorted according to the -log10 p-value) were selected to draw the heat map. b The KEGG pathways involving proteome difference between 2D monolayer and 3D MTS (p-value < 0.05, top 20 sorted according to the -log10 p-value). c Chord diagram of GO analysis. The top 6 GO terms with the number of differential proteins between 3 and 50 were selected (sorted according to the -log10 p-value in descending order). The relationship between the selected GO terms and the corresponding differential proteins were shown in the chord diagram. d Protein–protein interaction network of the top 25 proteins in connectivity degree. The molecular chaperones related to protein folding, assembly, and secretion exerted the most obvious effects, and the heat shock protein family was dominant. Left, before the 5-FU treatment; Right, after the 5-FU treatment

Back to article page