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Fig. 6 | Bioresources and Bioprocessing

Fig. 6

From: Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model

Fig. 6

Metabolomic differences between cells in 2D monolayer and 3D MTS. a Heatmap of differential metabolites between 2D monolayer and 3D MTS. 50 differential metabolites in the top KEGG pathways (sorted according to the -log10 p-value) were selected. b The KEGG pathways involving metabolome difference between 2D monolayer and 3D MTS (p-value < 0.05, top 20 sorted according to the -log10 p-value). Left, before the 5-FU treatment; Right, after the 5-FU treatment

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