Fig. 5
From: Toward improved terpenoids biosynthesis: strategies to enhance the capabilities of cell factories
Schematic illustration of adaptive laboratory evolution (ALE), atmospheric and room-temperature plasma (ARTP), and modular co-culture. A Microorganisms are exposed to a desired selective mechanism and or environment for an iterative period enabling natural selection to optimize variants with enhanced fitness. Genome sequencing and transcriptome can be used to analyze mutant variants. B Modular co-culture engineering. Segregating pathway into modules ensures a holistic assessment of each part for efficient optimization and improvement