Table 9 Main pharmacokinetic parameters of COS 2 and COS 3 in rat tissues after intragastric administration (n = 5)
From: Pharmacokinetics, bioavailability and tissue distribution of chitobiose and chitotriose in rats
Analyte | Organs | Cmax (mg/L) | Tmax (h) | AUC0-t (mg/L·h) | AUC0-∞ (mg/L·h) | MRT0-t (h) | t1/2z (h) |
|---|---|---|---|---|---|---|---|
COS 2 | Heart | 0.62 ± 0.05 | 2.00 ± 0.00 | 4.84 ± 0.76 | 12.46 ± 4.33 | 5.50 ± 0.27 | 13.43 ± 4.55 |
Liver | 0.53 ± 0.05 | 1.33 ± 0.58 | 4.02 ± 0.32 | 7.08 ± 2.01 | 5.21 ± 0.40 | 9.18 ± 3.58 | |
Kidney | 4.33 ± 1.13 | 1.33 ± 0.58 | 13.82 ± 4.68 | 14.02 ± 4.53 | 2.48 ± 0.21 | 1.75 ± 0.55 | |
Lung | 0.52 ± 0.03 | 1.33 ± 0.58 | 1.96 ± 0.26 | 2.51 ± 0.37 | 3.08 ± 0.19 | 3.52 ± 0.68 | |
Spleen | 0.31 ± 0.08 | 1.33 ± 0.58 | 1.02 ± 0.16 | 1.35 ± 0.33 | 3.11 ± 0.27 | 3.88 ± 2.09 | |
Pancreas | 0.47 ± 0.29 | 1.00 ± 0.00 | 1.07 ± 0.13 | 1.84 ± 0.90 | 2.80 ± 0.80 | 4.37 ± 3.26 | |
COS 3 | Heart | 1.04 ± 0.12 | 0.5 ± 0.43 | 4.43 ± 0.41 | 5.40 ± 0.86 | 4.01 ± 0.14 | 5.18 ± 1.75 |
Liver | 1.41 ± 0.26 | 1.08 ± 0.88 | 6.04 ± 1.18 | 8.54 ± 1.17 | 5.03 ± 0.33 | 8.26 ± 7.48 | |
Kidney | 4.85 ± 0.58 | 0.75 ± 0.43 | 15.53 ± 3.75 | 17.96 ± 7.70 | 3.16 ± 1.40 | 2.88 ± 1.95 | |
Lung | 2.99 ± 0.25 | 1.33 ± 0.58 | 6.40 ± 0.48 | 7.06 ± 1.16 | 2.49 ± 0.44 | 1.85 ± 0.84 |