Fig. 2

Proposed central metabolism pathways of strain MA5. maxF methanol dehydrogenase, gfa S-(hydroxymethyl)glutathione synthase, frmA S-(hydroxymethyl)glutathione dehydrogenase, frmB S-formylglutathione hydrolase, fdh formate dehydrogenase, fhs formate-tetrahydrofolate ligase, purU formyltetrahydrofolate deformylase, folD methylene-tetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, glyA glycine hydroxymethyltransferase, sga serine glyoxylate transaminase, hprA glycerate dehydrogenase, gckA glycerate 2-kinase, gpmI 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, serA D-3-phosphoglycerate dehydrogenase, serC phosphoserine aminotransferase’, serB phosphoserine phosphatase, eno enolase, ppc phosphoenolpyruvate carboxylase, pckA phosphoenolpyruvate carboxykinase, mdh malate dehydrogenase, mtkB malate-CoA ligase, mcl malyl-CoA/(S)-citramalyl-CoA lyase, agxt2 alanine-glyoxylate transaminase, tpiA triosephosphate isomerase, fbaA fructose-bisphosphate aldolase, pfkA 6-phosphofructokinase, fbp fructose-1,6-bisphosphatase, pgi glucose-6-phosphate isomerase, gck glucokinase, pyk pyruvate kinase, gltA citrate synthase, acnA aconitate hydratase, icd isocitrate dehydrogenase, sucA 2-oxoglutarate dehydrogenase E1 component, sucB 2-oxoglutarate dehydrogenase E2 component, sucD succinyl-CoA synthetase alpha subunit, aarC succinyl-CoA:acetate CoA-transferase, frdA fumarate reductase flavoprotein subunit, fumAB fumarate hydratase, narGHI nitrate reductase, nirBS nitrite reductase, norB nitric oxide reductase, nosZ nitrous oxide reductase, gdhA glutamate dehydrogenase. Dotted arrows indicate multistep reactions